Targeting Colorectal Cancer Liver Metastasis Through Repurposing Metabolic and Immune Inhibitors: A Theoretical Study
Published in Computational Biology and Chemistry (Elsevier), 2024
We present a theoretical systems biology model for identifying therapeutic combinations of metabolic and immune pathway inhibitors to treat colorectal cancer liver metastasis (CRLM). The study proposes novel repurposing strategies using Boolean networks and simulations of pathway dynamics to predict effective single and combination therapies. This paper is under review.